Forensic Science International
Volume 96, Issue 1 , Pages 61-70, 31 August 1998

Methamphetamine — properties and analytical methods of enantiomer determination

  • David Jirovský

      Affiliations

    • Laboratory of Bioanalytical Research, Palacký University, Tř. Svobody 8, 771 46 Olomouc, Czech Republic
    • Corresponding Author InformationCorresponding author.
  • ,
  • Karel Lemr

      Affiliations

    • Laboratory of Bioanalytical Research, Palacký University, Tř. Svobody 8, 771 46 Olomouc, Czech Republic
    • Department of Analytical Chemistry, Faculty of Science, Palacký University, Tř. Svobody 8, 771 46 Olomouc, Czech Republic
  • ,
  • Juraj Ševčı́k

      Affiliations

    • Laboratory of Bioanalytical Research, Palacký University, Tř. Svobody 8, 771 46 Olomouc, Czech Republic
    • Department of Analytical Chemistry, Faculty of Science, Palacký University, Tř. Svobody 8, 771 46 Olomouc, Czech Republic
  • ,
  • Břetislav Smysl

      Affiliations

    • Institute of Forensic Medicine and Medical Law, Faculty of Medicine, Palacký University, Hněvotı́nská, 3775 09 Olomouc, Czech Republic
  • ,
  • Zdeněk Stránský

      Affiliations

    • Department of Analytical Chemistry, Faculty of Science, Palacký University, Tř. Svobody 8, 771 46 Olomouc, Czech Republic

Received 24 June 1997; accepted 17 June 1998.

Abstract 

Methamphetamine is one of the most frequently abused drugs of today. Due to its stereogenic center, it can exist as single enantiomer. Like many other chiral compounds, methamamphetamine enantiomers exhibit different pharmacological effects on living organisms. For this reason, it is necessary to develop enantioselective and sufficiently sensitive methods of determination. This review focuses on methamphetamine with an accent on analytical chemistry and especially on chiral separations of this toxicologically important compound.

Keywords:  Methamphetamine, Enantiomer

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PII: S0379-0738(98)00104-2

Forensic Science International
Volume 96, Issue 1 , Pages 61-70, 31 August 1998