Molecular pathology of wound healing☆
Abstract
Skin-wound healing is an orchestrated biological phenomena consisting of three sequential phases, inflammation, proliferation, and maturation. Many biological substances are involved in the process of wound repair, and this short and simplified overview of wound healing can be adopted to determine wound vitality or wound age in forensic medicine. With the development of genetically engineered animals, essential molecules for skin-wound healing have been identified. Especially, cytokines, and growth factors are useful candidates and markers for the determination of wound vitality or age. Moreover, bone marrow-derived progenitor cells would give significant information to wound age determination. In this review article, some interesting observations are presented, possibly contributing to the future practice of forensic pathologists.
Keywords: Wound healing, Wound age, Growth factors, Cytokines, Bone marrow-derived cells
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☆ This paper is part of the special issue entitled: Molecular Pathology in Forensic Medicine, Guest-edited by Burkhard Madea and Pekka Saukko.
PII: S0379-0738(10)00333-6
doi:10.1016/j.forsciint.2010.07.004
© 2010 Published by Elsevier Inc.
