Forensic Science International
Volume 158, Issue 2 , Pages 157-163 , 10 May 2006

Time-course changes in the expression of heme oxygenase-1 in human subcutaneous hemorrhage

  • Toru Nakajima

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • Department of Plastic Surgery, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 43 226 2078; fax: +81 43 226 2079.
    • ,
  • Mutsumi Hayakawa

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Daisuke Yajima

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Hisako Motani-Saitoh

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Yayoi Sato

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Masahiro Kiuchi

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Masaharu Ichinose

      Affiliations

    • Department of Plastic Surgery, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan
    • ,
  • Hirotaro Iwase

      Affiliations

    • Department of Legal Medicine, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan

Received 26 November 2004 ,Accepted 19 May 2005.

References 

  1. Langlois NEI, Gresham GA. The ageing of bruises: a review and study of the colour changes with time. Forensic Sci. Int. 1991;50:227–238
  2. Y. Yajima, M. Nata, M. Funayama, Spectrophotometric and tristimulus analysis of the colors of subcutaneous bleeding in living persons, Legal Med. (Tokyo) 5 (Suppl. 1) (2003) S342–S343.
  3. Hughes VK, Ellis PS, Burt T, Langlois NE. The practical application of reflectance spectrophotometry for the demonstration of haemoglobin and its degradation in bruises. J. Clin. Pathol. 2004;57:355–359
  4. Betz P, Nerlich A, Wilske J, Tübel J, Wiest I, Penning R, et al. Immunohistochemical localization of fibronectin as a tool for the age determination of human skin wounds. Int. J. Legal Med. 1992;105:21–26
  5. Betz P, Nerlich A, Wilske J, Tübel J, Penning R, Eisenmenger W. Time-dependent appearance of myofibroblasts in glanulation tissue of human skin wounds. Int. J. Legal Med. 1992;105:99–103
  6. Betz P, Nerlich A, Wilske J, Tübel J, Penning R, Eisenmenger W. The time-dependent localization of Ki67 antigen-positive cells in human skin wounds. Int. J. Legal Med. 1993;106:35–40
  7. Betz P. Histological and enzyme histochemical parameters for the age estimation of human skin wounds. Int. J. Legal Med. 1994;107:60–68
  8. Kondo T, Ohshima T. The dynamics of inflammatory cytokines in the healing process of mouse skin wound: a preliminary study for possible wound age determination. Int. J. Legal Med. 1996;108:231–236
  9. Betz P, Eisenmenger W. Morphometrical analysis of hemosiderin deposits in relation to wound age. Int. J. Legal Med. 1996;108:262–264
  10. Dreßler J, Bachmann L, Kasper M, Hauck JG, Müller E. Time dependence of the expression of ICAM-1 (CD 54) in human skin wounds. Int. J. Legal Med. 1997;110:299–304
  11. Betz P, Nerlich A, Tübel J, Wiest I, Hausmann R. Detection of cell death in human skin wounds of various ages by an in situ end labeling of nuclear DNA fragments. Int. J. Legal Med. 1997;110:240–243
  12. Hausmann R, Nerlich A, Betz P. The time-related expression of p53 protein in human skin wounds—a quantitative immunohistochemical analysis. Int. J. Legal Med. 1998;111:169–172
  13. Dreβler J, Bachmann L, Koch R, Müller E. Estimation of wound age and VCAM-1 in human skin. Int. J. Legal Med. 1999;112:159–162
  14. Kondo T, Ohshima T, Eisenmenger W. Immunohistochemical and morphometrical study on the temporal expression of interleukin-1α (IL-1α) in human skin wounds for forensic wound age determination. Int. J. Legal Med. 1999;112:249–252
  15. Ohshima T. Forensic wound examination. Forensic Sci. Int. 2000;113:153–164
  16. Dressler J, Bachmann L, Strejc P, Koch R, Müller E. Expression of adhesion molecules in skin wounds: diagnostic value in legal medicine. Forensic Sci. Int. 2000;113:173–176
  17. Grellner W, Georg T, Wilske J. Quantitative analysis of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds. Forensic Sci. Int. 2000;113:251–264
  18. Kondo T, Ohshima T, Sato Y, Mayama T, Eisenmenger W. Immunohistochemical study on the expression of c-Fos and c-Jun in human skin wounds. Histochem. J. 2000;32:509–514
  19. Ohshima T. The dynamics of cytokines and their related substances in skin wounds. Nippon Hoigaku Zasshi. 2000;54:346–355
  20. Dreßler J, Busuttil A, Koch R, Harrison DJ. Sequence of melanocyte migration into human scar tissue. Int. J. Legal Med. 2001;115:61–63
  21. Psaroudakis K, Tzatzarakis MN, Tsatsakis AM, Michalodimitrakis MN. The application of histochemical methods to the age evaluation of skin wounds: experimental study in rabbits. Am. J. Forensic Med. Pathol. 2001;22:341–345
  22. Kondo T, Ohshima T, Mori R, Guan DW, Ohshima K, Eisenmenger W. Immunohistochemical detection of chemokines in human skin wounds and its application to wound age determination. Int. J. Legal Med. 2002;116:87–91
  23. Takamiya M, Saigusa K, Aoki Y. Immunohistochemical study of basic fibroblast growth factor and vascular endothelial growth factor expression for age determination of cutaneous wounds. Am. J. Forensic Med. Pathol. 2002;23:264–267
  24. Kondo T, Tanaka J, Ishida Y, Mori R, Takayasu T, Ohshima T. Ubiquitin expression in skin wounds and its application to forensic wound age determination. Int. J. Legal Med. 2002;116:267–272
  25. Grellner W. Time-dependent immunohistochemical detection of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds. Forensic Sci. Int. 2002;130:90–96
  26. Fieguth A, Feldbrügge H, Gerich T, Kleemann WJ, Tröger HD. The time-dependent expression of fibronectin, MRP8, MRP14 and defensin in surgically treated human skin wounds. Forensic Sci. Int. 2003;131:156–61
  27. Takamiya M, Saigusa K, Nakayashiki N, Aoki Y. Studies on mRNA expression of basic fibroblast growth factor in wound healing for wound age determination. Int. J. Legal Med. 2003;117:46–50
  28. Bonelli A, Bacci S, Norelli GA. Affinity cytochemistry analysis of mast cells in skin lesions: a possible tool to assess the timing of lesions after death. Int. J. Legal Med. 2003;117:331–334
  29. Laiho K, Tenhunen R. Hemoglobin-degrading enzymes in experimental subcutaneous hematomas. Z. Rechtsmed. 1984;93:193–198
  30. Thornton RN, Jolly RD. The objective interpretation of histopathological data: an application to the ageing of ovine bruises. Forensic Sci. Int. 1986;31:225–239
  31. Sawaguchi T, Jasani B, Kobayashi M, Knight B. Post-mortem analysis of apoptotic changes associated with human skin bruises. Forensic Sci. Int. 2000;108:187–203
  32. Oehmichen M, Windisch A, Meissner C. Mononuclear cells in subcutaneous haemorrhage with special consideration of myeloid percursor cells. Med. Sci. Law. 2000;40:286–292
  33. Tenhunen R, Marver HS, Schmid R. Microsomal heme oxygenase: characterization of the enzyme. J. Biol. Chem. 1969;244:6388–6394
  34. Pimstone NR, Tenhunen R, Seitz PT, Marver HS, Schmid R. The enzymatic degradation of hemoglobin to bile pigments by macrophages. J. Exp. Med. 1971;133:1264–1281
  35. Willis D, Moore AR, Frederick R, Willoughby DA. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat. Med. 1996;2:87–90
  36. McCoubrey WK, Huang TJ, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur. J. Biochem. 1997;247:725–732
  37. Elbirt KK, Bonkovsky HL. Heme oxygenase: recent advances in understanding its regulation and role. Proc. Assoc. Am. Physicians. 1999;111:438–447
  38. Dong Z, Lavrovsky Y, Venkatachalam MA, Roy AK. Heme oxygenase-1 in tissue pathology: the Yin and Yang. Am. J. Pathol. 2000;156:1485–1488
  39. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 1997;37:517–554
  40. Kämpfer H, Kolb N, Manderscheid M, Wetzler C, Pfeilschifter J, Frank S. Macrophage-derived heme-oxygenase-1: expression, regulation, and possible functions in skin repair. Mol. Med. 2001;7:488–498
  41. Leibovich SJ, Ross R. The role of the macrophage in wound repair: a study with hydrocortisone and antimacrophage serum. Am. J. Pathol. 1975;78:71–100
  42. DiPietro LA. Wound healing: the role of the macrophage and other immune cells. Shock. 1995;4:233–240
  43. Martin P. Wound healing—aiming for perfect skin regeneration. Science. 1997;276:75–81
  44. Heinrich SA, Messingham KA, Gregory MS, Colantoni A, Ferreira AM, DiPietro LA, et al. Elevated monocyte chemoattractant protein-1 levels following thermal injury precede monocyte recruitment to the wound site and are controlled, in part, by tumor necrosis factor-alpha. Wound Repair Regen. 2003;11:110–119

PII: S0379-0738(05)00320-8

doi: 10.1016/j.forsciint.2005.05.028

Forensic Science International
Volume 158, Issue 2 , Pages 157-163 , 10 May 2006

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