Forensic Science International
Volume 153, Issue 1 , Pages 45-51 , 4 October 2005

Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol

  • Luis A. Ferrari

      Affiliations

    • Laboratory of Toxicology and Legal Chemistry, Court of Justice of the Province of Buenos Aires, 41 and 119, 1900 La Plata, Argentina
    • Department of Toxicology, U.M. University, Cabildo 134, Morón, Buenos Aires, Argentina
    • Corresponding Author InformationCorresponding author. Tel.: +54 221 4722365
  • ,
  • Leda Giannuzzi

      Affiliations

    • Toxicology and Legal Chemistry, National University of La Plata, 47 and 115, 1900 La Plata, Argentina
    • el.: +54 221 4227303.

References 

  1. Mathews JM, Parker MK, Mathews HB. Metabolism and disposition of diethyelene glycol in rat and dog. Drug Metabol. Dispos. 1991;19(6):1066–1070
  2. MSDS, Material Safety Data Sheet, Canadian Centre for Occupational Health and Safety
  3. Geiling EM, Cannon PR. Pathologic effects of elixir of sulphanilamide (diethylene glycol) poisoning. J. Am. Med. Assoc. 1938;111:919–926
  4. Calvery HO, Klampp TG. The toxicity for human beings of diethylene glycol with sulphanilamide. S. Med. J. 1939;32:1105–1109
  5. Bowie MD, Mc Kenzie D. Diethylene glycol poisoning in children. S. Afr. Med. J. 1972;46(9):931–934
  6. Pandya SK. An unmitigated tragedy. Br. Med. J. 1988;297:117–119
  7. Okuonghae HO, Ighogboja IS, Lawson JO, Nwana EJC. Diethylene glycol poisoning in Nigerian children. Ann. Trop. Pediatr. 1992;12:235–238
  8. Hanif M, Mobarax MR, Ronon A, Rahman D, Donovan JJ, Bennish ML. Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic. Br. Med. J. 1995;311:88–91
  9. O’Brien KL, Selanikio JD, Hecdivert C, Placide MF, Louis M, Barr DB, et al. Epidemic of paediatric deaths from acute renal failure caused by diethylene glycol poisoning. J. Am. Med. Assoc. 1998;279:1175–1180
  10. Ferrari LA, Arado MG, Wamba Z, Stoichevich M, Stoichevich S, Diethylene Glycol . (DEG) in human organs from victims of a massive intoxication with contaminated propolis syrup. In: Proceedings of the 35th TIAFT Meeting. Padova, Italy. 1997;p. 625–630
  11. Dimov V, Ivanovska N, Manolova N, Bankova V, Nokolov N, Papov S. Inmunomodulatory action of propolis influence on anti-infections protection and macrophage function. Epidemiology. 1991;22:155–162
  12. Maresta L. Antibacterial activity of flavonoid compounds of propolis, occurring in flora in Poland. Bull. Vet. Ins. Pulawy. 1986;28:61–64
  13. N.C. Jain, R. Forney, Propylene glycol and ethylene glycol type C procedure, in: I. Sunshine (Ed.), Methodology for Analytical Toxicology, vol. I, CRC Press, Boca Raton, Florida, 1975, pp. 165–166.
  14. Stoichevich de Suñol M, Wamba Z. Informe Pericial Q-1220. [Expert witness report Q-1220]. La Plata: Biblioteca de la Asesoría Pericial; 1992;
  15. Wiener HL, Richardson KE. Metabolism of diethylene glycol in male rats. Biochem. Pharmacol. 1989;38:539–541
  16. Lenk W, Lohr D, Sonnenbichler J. Pharmacokinetics and biotransformation of diethylene glycol and ethylene glycol in the rat. Xenobiotica. 1989;19(9):961–979
  17. Herbert JL, Fabre M, Auzepy P, Paillas J, Durand A. Acute experimental poisoning by DEG: acid base balance and histological data in male rats. Toxicol. Eur. Res. 1978;1:289–294
  18. Morris HJ, Nelson AA, Calvery HO. Observations on the chronic toxicities of propylene glycol, ethylene glycol diethylene glycol. J. Pharmacol. Exp Ther. 1942;74:266–273
  19. Garrote V, Mirson D, Krbavcic I, Nardo C, Arado M, Nieto R, et al. Alcohols and cocaine postmortem stability in human organs and blood.. In:  Rasanen I editors. Proceedings of TIAFT 2000. 2001;p. 263–270
  20. Leec PN. Elixir of sulphanilamide–Massengill. Chemical, pharmacologic, pathologic and necropsy reports: preliminary toxicity reports on diethylene glycol and sulphanilamide. J. Am. Med. Assoc. 1937;109:1531–1539
  21. Laug EP, Calvery HO, Morris HJ, Woodard G. The toxicity of some glycols and derivatives. J. Ind. Hyg. Toxicol. 1939;21:173–201

PII: S0379-0738(05)00207-0

doi: 10.1016/j.forsciint.2005.04.038

Forensic Science International
Volume 153, Issue 1 , Pages 45-51 , 4 October 2005