Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys
Abstract
The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and female Sprague–Dawley rats were given 2,4-D in drinking water and food for 30 days. Group A (control group) was fed a normal diet, Group B was fed 50
ppm 2,4-D in 15
g food, Group C received 100
ppm 2,4-D in 15
g food, Group D received 25
ppm 2,4-D in 15
ml drinking water and Group E was given 50
ppm 2,4-D in 15
ml of drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high performance liquid chromatography (HPLC). It was observed that at low doses of 2,4-D, the metabolite, 2,4-DCP found in the kidneys.
Abbreviations: 2,4-D, 2,4-dichlorophenoxyacetic acid, 2,4-DCP, 2,4-dichlorophenol
Keywords: 2,4-Dichlorophenoxyacetic acid (2,4-D), 2,4-Dichlorophenol (2,4-DCP), HPLC, Kidney accumulation, Rat
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PII: S0379-0738(05)00206-9
doi:10.1016/j.forsciint.2005.04.018
© 2005 Elsevier Ireland Ltd. All rights reserved.
