Forensic Science International
Volume 118, Issue 2 , Pages 147-152, 15 May 2001

Allele sequences of six new Y-STR loci and haplotypes in the Chinese Han population

  • Y.P. Hou

      Affiliations

    • Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, 610041 Sichuan, PR China
    • Corresponding Author InformationCorresponding author. Fax: +86-28-5438252
    • ,
  • J. Zhang

      Affiliations

    • Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, 610041 Sichuan, PR China
    • ,
  • Y.B. Li

      Affiliations

    • Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, 610041 Sichuan, PR China
    • ,
  • J. Wu

      Affiliations

    • Institute of Forensic Medicine, West China University of Medical Sciences, Chengdu, 610041 Sichuan, PR China
    • ,
  • S.Z. Zhang

      Affiliations

    • Department of Medical Genetics, West China University of Medical Sciences, Chengdu, 610041 Sichuan, PR China
    • ,
  • M. Prinz

      Affiliations

    • Department of Forensic Biology, OCME, 520 First Avenue, New York, NY 10016, USA

Received 7 September 2000; accepted 16 September 2000.

Abstract 

Human chromosome Y-specific short tandem repeat (Y-specific STR) markers have useful properties for forensic applications. However, there is a need to develop more Y-specific STR markers, because the discriminating power of each STR locus is limited. In the present study, we describe our results on six new Y-specific STR markers that were initially located using sequence database information by Ayub et al. and were named DYS434, DYS435, DYS436, DYS437, DYS438 and DYS439. Our studies focused on the analysis of the DNA sequence for each allele at all six Y-specific STR loci in order to understand their structures in the human genome and to construct human allelic ladders, which are necessary for forensic DNA typing. In addition, the haplotype distribution for all six analyzed loci was studied in a Chinese Han population sample. The results indicate that DYS434, DYS435, DYS436, DYS437, DYS438 and DYS439 are useful Y-specific STR markers for forensic sciences.

Keywords: Y-chromosome, Short tandem repeats, DYS434, DYS435, DYS436, DYS437, DYS438, DYS439, Sequences, Haplotypes, Chinese Han population

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PII: S0379-0738(01)00383-8

doi:10.1016/S0379-0738(01)00383-8

Forensic Science International
Volume 118, Issue 2 , Pages 147-152, 15 May 2001

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