Sequence analysis and population data on the ‘new’ short tandem repeat locus D5S2360☆

Received 24 January 2000; received in revised form 18 July 2000; accepted 20 July 2000.

Abstract

We have studied the sequence structure and population genetics of a ‘new’ short tandem repeat polymorphism at locus D5S2360 in German Caucasians. Sequencing at this locus revealed a considerable variation, which is characterized by a tetranucleotide (AGAT)n repeat pattern with (GAT), (AGATT), and (AG) repeats dispersed throughout the alleles. These microvariations do not necessarily alter the size of the alleles. They may vary by one or two pairs or they may remain unchanged in size. At locus D5S2360 we observed 33 allelic lengths comprising at least 36 different alleles. Population data revealed a high polymorphism with a heterozygosity rate of approximately 92.5%.

Keywords: DNA, STR, D5S2360, Sequence analysis, Population genetics, Forensic genetics

a Institut für Blutgruppenforschung, Hohenzollernring 57, 50672 Koeln, Germany

b Institut für Medizinische Biometrie, Informatik und Epidemiologie der Rheinischen Friedrich-Wilhelms-Universität, Bonn, Germany

c Labor Dr. Arnold, Wuerzburg, Germany

Corresponding author. Tel.: +49-221-253037; fax: +49-221-251247

☆ Preliminary results were presented at the 18th ISFH congress, San Francisco, CA, USA, 17–21 August 1999.

PII: S0379-0738(00)00349-2

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