Forensic Science International
Volume 115, Issue 3 , Pages 171-181 , 15 January 2001

Morphometric assessment of testicular changes in drug-related fatalities

  • J Reuhl

      Affiliations

    • Institute of Forensic Medicine, University of Mainz, Am Pulverturm 3, D-55131 Mainz, Germany
    • Corresponding Author InformationCorresponding author.
    • ,
  • M Bachl

      Affiliations

    • Department of Surgery, St. Vinzenz Hospital, Auf dem Schafsberg, D-65549 Limburg, Germany
    • ,
  • M Schneider

      Affiliations

    • Senckenberg Center of Pathology, University of Frankfurt/Main, Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany
    • ,
  • F.-U Lutz

      Affiliations

    • Center of Forensic Medicine, University of Frankfurt/Main, Kennedyallee 104, D-60596 Frankfurt am Main, Germany
    • ,
  • H Bratzke

      Affiliations

    • Center of Forensic Medicine, University of Frankfurt/Main, Kennedyallee 104, D-60596 Frankfurt am Main, Germany

Received 10 November 1998 ,Revised 22 May 2000 ,Accepted 9 June 2000.

References 

  1. Kringsholm B, Christoffersen P. Liver pathology in fatal drug addiction. Forensic Sci. Int. 1982;20:141–151
  2. Paties C, Peveri V, Falzi G. Liver histopathology in autopsied drug addicts. Forensic Sci. Int. 1987;35:11–26
  3. Gerlach D. Post-mortem investigations of fatal cases of narcotic addiction. Forensic Sci. Int. 1980;15:31–39
  4. Keul H-G, Schäfer V, Lörcher U, Schneider M, Lutz F-U, Reuhl J. Preliminary results of an interdisciplinary survey of drug victims. Forensic Sci. Int. 1993;62:147–149
  5. Byers JM, Soin JS, Fisher RS, Hutchins GM. Acute pulmonary alveolitis in narcotics abuse. Arch. Pathol. 1975;99:273–278
  6. Gerlach D. Histopathologische Befunde bei Rauschmittelkonsumenten. Z. Rechtsmedizin. 1978;80:299–304
  7. Püschel K, Schoof W. Zur Morphogenese hämatogen entstandener Fremdkörpergranulome im Lungenparenchym. Beitr. Gerichtl. Med. 1986;24:121–128
  8. Tomashefski JF, Hirsch CS. The pulmonary vascular lesions of intravenous drug abuse. Hum. Pathol. 1980;11:133–145
  9. Smith HJ, Roche AHG, Jagusch MF, Herdson PB. Cardiomyopathy associated with amphetamine administration. Am. Heart J. 1976;91:792–797
  10. Kringsholm B, Christoffersen P. Lung and heart pathology in fatal drug addiction: a consecutive autopsy study. Forensic Sci. Int. 1987;34:39–51
  11. Kringsholm B, Christoffersen P. Spleen and portal lymph node pathology in fatal drug addiction. Forensic Sci. Int. 1984;25:233–244
  12. Gerlach D. Post-mortem investigations of fatal cases of narcotic addiction. Forensic Sci. Int. 1980;15:31–39
  13. Latasch L, Schneider M, Steinau U. Morphologische Befunde an Skelettmuskelbiopsien bei Drogenabhängigen. Klinikarzt. 1986;15:252–256
  14. Thompson GR, Mason MM, Rosenkrantz H, Braude MC. Chronic oral toxicity of cannabinoids in rats. Toxicol. Appl. Pharmacol. 1973;25:373–390
  15. Barroso-Moguel R, Mendez-Armenta M. Testicular lesions by chronic administration of cocaine in rats. J. Appl. Toxicol. 1994;14:37–41
  16. Rodriguez MC, Sanchez-Yague J, Paniagua R. Effects of cocaine on testicular structure in the rat. Reprod. Toxicol. 1992;6:51–55
  17. Suh JH, Yank BK, Lim DK, Jhoo WK, Kim HC. Testicular degeneration and sperm loss induced by chronic administration of cocaine in mice. Arch. Pharmacol. Res. 1994;17:213–217
  18. Bracken MB, Eskenazi B, Sachse K, Mc Sharry JE, Hellenbrand K, Leo-Summers L. Association of cocaine use with sperm concentration, motility, and morphology. Fertil. Steril. 1990;53(2):315–322
  19. el Gothamy Z, el Samahy M. Ultrastructure sperm defects in addicts. Fertil. Steril. 1992;57:699–702
  20. Wilson B. The effect of drugs on male sexual function and fertility. Nurse Pract. 1991;16:127–214
  21. Joesoef MR, Beral V, Aral SO, Rolfs RT, Cramer DW. Fertility and use of cigarettes, alcohol, Marijuana, and cocaine. Ann. Epidemiol. 1993;3:592–594
  22. Kyrle H. Über Strukturanomalien im menschlichen Hodenparenchym. Verh. Dtsch. Ges. Pathol. 1909;13:391–395
  23. van Thiel DH, Gavaler JS, Lester R, Goodman MD. Alcohol-induced testicular atrophy. Gastroenterology. 1975;69:326–332
  24. Johnsen SG. Testicular biopsy score count — a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones. 1970;1:2–25
  25. Weibel ER, Gomez DM. A principle for counting tissue structures on random sections. J. Appl. Physiol. 1962;17:343–348
  26. Sittaro N-A. Bewertung und Tarifierung von Übergewicht mit Hilfe des Body-Mass-Index. Versicherungsmedizin. 1994;46:216–221
  27. Bschor F, Wessel J. Sterblichkeit Drogenabhängiger im internationalen Vergleich. Lebensversicherungsmedizin. 1983;35:74–80
  28. Frei D, Hedinger C. Arterioläre Hyalinose in Hodenbiopsien. Virchows Arch. (A). 1979;381:269–281
  29. Regedera J, Nistal M, Paniagua R. Testis, epididymis, and spermatic cord in elderly men. Arch. Pathol. Lab. Med. 1985;109:663–667
  30. Paniagua R, Nistal M, Amat P, Rodriguez MC, Martin A. Seminiferous tubule involution in autopsied drug addicts. Biol. Reprod. 1987;35:11–26
  31. Littmann KP. Hypogonadismus und Androgenstoffwechsel bei Lebererkrankungen. Internist. 1978;36:433–437
  32. Boiesen PT, Lindholm J, Hagen C, Bahnsen N, Fabricius-Bjerre N. Histological changes in testicular biopsies from chronic alcoholics with and without liver disease. Acta Pathol. Microbiol. Immunol. Scand. (A). 1979;87:139–142
  33. Handelsman DJ, Stara S. Testicular size: the effects of aging, malnutrition, and illness. J. Androl. 1985;6:144–151
  34. Prijono H, Schirren U. Die Bedeutung des Tubulusdurchmessers im Hodenbiopsiematerial bei Oligozoospermie. Andrologia. 1985;17:541–545
  35. Pesce C, Reale A. Testis biopsy for infertility: a comparative assessment of current score methods for the evaluation of the histological specimen. Int. J. Fertil. 1985;30:7–12
  36. T.D. Trainer, Testis and excretory duct system, in: S.S. Sternberg (Ed.), Histology for Pathologists, Raven Press, New York, 1992, pp. 731–747.
  37. C.E. Hedinger, Pathologie des Hodens, in: W. Doerr, G. Seifert, E. Uehlinger (Eds.), Spezielle pathologische Anatomie, Vol. 21, Pathologie des männlichen Genitale, Springer, Berlin, Heidelberg, New York, London, Paris, Hong Kong, Barcelona, 1991, pp. 1–452.
  38. Koudstaal J, Frensdorf EL, Kremer J, Mudde JM, Hardonk MJ. A clinical and histochemical study of disorders of the human testes. Acta Endocrinol. (Copenhag.). 1967;55:427–439
  39. Mikuz G, Leitner G, Scheiber K, Bartsch G. Correlation of hormone levels and quantitative histological findings in testicular biopsies. Eur. Urol. 1985;11:110–116
  40. Dykes JRW. Histometric assessment of human testicular biopsies. J. Pathol. 1969;97:429–440
  41. Chabon AB, Stenger RJ, Grabstald H. Histopathology of testis in acquired immune deficiency syndrome. Urology. 1987;29:658–663
  42. Trübner K, Püschel K, Laufs R. Hepatitis bei Rauschgifttoten. Z. Rechtsmed. 1989;102:199–205
  43. M. Nistal, R. Paniagua, Testicular lesions secondary to physical-chemical agents, dietary deficiencies, and peripheral nervous system lesions, in: Testicular and Epididymal Pathology, Thieme-Stratton, Inc., Stuttgart, New York, 1984.
  44. Mikuz G, Schwarz C, Bartsch G. Wert der semiquantitativen morphologischen Beurteilung von Hodenbiopsien bei Fertilitätsstörungen des Mannes. Pathologe. 1983;4:244–251
  45. Cregler LL. Adverse health consequences of cocaine abuse. J. Nat. Med. Assoc. 1989;81:27–38
  46. Virmani R, Robinowitz M, Smialek JE, Smyth DF. Cardiovascular effects of cocaine: an autopsy study of 40 patients. Am. Heart J. 1988;115:1068–1076
  47. Heilmann K, Höpker W, Linhart P, Weizel A. Vergleichende morphologische Untersuchungen von Leberbiopsien bei Drogensüchtigen. Verh. Dtsch. Ges. Pathol. 1972;56:494–498
  48. Rajs J, Falconer B. Cardiac lesions in intravenous drug addicts. Forensic Sci. Int. 1979;13:193–209

PII: S0379-0738(00)00327-3

Forensic Science International
Volume 115, Issue 3 , Pages 171-181 , 15 January 2001

Article Tools

* Image Usage & Resolution